Ex27: Multi-Synapses

Multiple synapse types on single connections

Model: Multi-Synapses

Demonstrates multiple synapse types between the same pre/post cell pair, showing how different receptor types (AMPA, NMDA, GABA) can coexist on a single connection with different kinetics.

---

1. Define IaF Cell in TVBO

from tvbo import SimulationExperiment

exp = SimulationExperiment.from_string("""
label: "NeuroML Ex27: IaF with Multi-Synapses"
dynamics:
  name: IntegrateAndFire
  parameters:
    leakReversal: { value: -50.0 }
    tau:          { value: 30.0 }
    thresh:       { value: -55.0 }
    reset:        { value: -70.0 }
  state_variables:
    v:
      equation: { rhs: "(leakReversal - v) / tau" }
      initial_value: -50.0
      variable_of_interest: true
  events:
    spike:
      condition: { rhs: "v > thresh" }
      affect:    { rhs: "v = reset" }
network:
  number_of_nodes: 1
integration:
  method: euler
  step_size: 0.005
  duration: 300.0
  time_scale: ms
""")
print(f"Model: {exp.dynamics.name}")

Model: IntegrateAndFire

2. Render LEMS XML

xml = exp.render("lems")
print(xml[:1200])

<Lems>

  <!-- Tell jLEMS/jNeuroML which component is the simulation entry point. -->
  <Target component="sim_NeuroML_Ex27__IaF_with_Multi_Synapses"/>

  <!-- ════════════════════════════════════════════════════════════════
       Dimensions & Units (inline — no external includes needed)
       ════════════════════════════════════════════════════════════════ -->

  <!-- Dimensions -->
  <Dimension name="none"/>
  <Dimension name="time" t="1"/>
  <Dimension name="voltage" m="1" l="2" t="-3" i="-1"/>
  <Dimension name="per_time" t="-1"/>
  <Dimension name="conductance" m="-1" l="-2" t="3" i="2"/>
  <Dimension name="capacitance" m="-1" l="-2" t="4" i="2"/>
  <Dimension name="current" i="1"/>
  <Dimension name="resistance" m="1" l="2" t="-3" i="-2"/>
  <Dimension name="concentration" l="-3" n="1"/>
  <Dimension name="substance" n="1"/>
  <Dimension name="charge" t="1" i="1"/>
  <Dimension name="temperature" k="1"/>

  <!-- Units -->
  <Unit symbol="s" dimension="time" power="0"/>
  <Unit symbol="ms" dimension="time" power="-3"/>
  <Unit symbol="us" dimension="time" power="-6"/>
  <Unit symbol="V" dimension="voltage" power="0"/>
  <Unit symbol="mV" dimension="voltage" power="-3"/>
  <

3. Run Reference

import sys, os
sys.path.insert(0, os.path.dirname(os.path.abspath(".")))
from _nml_helpers import run_lems_example

ref_outputs = run_lems_example("LEMS_NML2_Ex27_MultiSynapses.xml")
for name, arr in ref_outputs.items():
    print(f"  {name}: shape={arr.shape}")

  ex27_v.dat: shape=(600001, 5)

4. Run TVBO

import numpy as np

result = exp.run("neuroml")
da = result.integration.data
tvbo_arr = np.column_stack([da.coords['time'].values, da.values])
print(f"TVBO: shape={tvbo_arr.shape}")

TVBO: shape=(60001, 2)

5. Plot Reference

import matplotlib.pyplot as plt
import numpy as np

for name, ref_arr in ref_outputs.items():
    t = ref_arr[:, 0] * 1000
    fig, ax = plt.subplots(figsize=(10, 4))
    for i in range(1, min(ref_arr.shape[1], 6)):
        ax.plot(t, ref_arr[:, i] * 1000, alpha=0.8, label=f'Cell {i}')
    ax.set_xlabel("Time (ms)")
    ax.set_ylabel("Voltage (mV)")
    ax.set_title(f"Ex27: Multi-Synapses — {name}")
    ax.legend(fontsize=7)
    ax.grid(True, alpha=0.3)
    plt.tight_layout()
    plt.show()

Multi-Synapses

Multiple synapse types (AMPA, NMDA, GABA) per connection is a NeuroML network feature. TVBO represents the cell dynamics; synaptic diversity is handled by the NeuroML adapter.